The region which will represent Cymru in the UEFA Regions' Cup will be determined in Briton Ferry this weekend.
Cymru North and Cymru South will meet for the play-off second leg at Old Road Welfare Ground on Sunday, with the aggregate score locked at 0-0 following a stalemate in the first leg at Denbigh Town.
Guy Handscombe selected players from Llanuwchllyn, Holywell Town, Colwyn Bay, Llanrhaeadr Ym Mochnant, Guilsfield, Holyhead Hotspur and Ruthin Town in the Cymru North starting XI for the first leg.
He was forced into a late change when Holywell's Dylan Allshorn pulled out late on through illness, which he felt disrupted his side's start, but says his players responded well.
"I think it was a fair result last weekend," said the Cymru North manager. "We had to make a big change before kick off with Dylan Allshorn not being well enough to play, which I don't think helped us at the start of the game.
"It would have been fantastic to take a 1-0 lead into the second leg, but we look at it as a cup final now and the winner takes all."
Llantwit Major defender Kristian Evans had the ball in the net for Cymru South in the first leg but saw the goal ruled out for offside as the game ended goalless.
It means it's all to play for in the second leg this weekend, with the away goals rule counting in the play-off. Another goalless draw would see the winning region determined by a penalty shoot-out.
"The first leg was surreal if I'm honest because there was a mystery behind the opposition, which is usually not the case," said Cymru South manager Jonathan Jones.
"I think the only thing we can leave that game disappointed with is the scoreline because we were very proud of all of the elements of our performance. We had a great start to the game and created good chances, so there were lots of positives and now we've had time to reflect on it.
"We wanted better but we know all about the opposition now with home advantage and the confidence we have from that performance in the north can only be a positive going into this weekend."
Jones enjoyed a memorable season with Pontypridd Town in the JD Cymru South this term after steering them to promotion to the JD Cymru Premier.
He confirmed his departure from the club earlier this week but wants to cap off an impressive 2021/22 campaign by guiding Cymru South to the UEFA Regions' Cup intermediate round.
"It would complete a full set of objectives for me this season if we're able to do it," added Jones.
"I've gained a place on the UEFA Pro Licence which was a personal career ambition and I'm thrilled with that. We achieved our objective of getting Pontypridd promoted to the JD Cymru Premier, and to cap it off this Sunday by guiding Cymru South to the UEFA Regions' Cup would be the final tick on the checklist.
"It would be a proud moment to represent Wales in the intermediate round would be another level of excitement."
Handscombe shares the same ambition as Jones and says leading the Cymru North into the intermediate round would rank among his highest.
"To lead this group of players to a tournament would be fantastic because they've bought into everything that we've tried to do since our first training session.
"The players have embraced everything and the key thing is I don't want this journey to end with them, so hopefully we can carry it forward into October. Personally and professionally it would be right up there as one of my biggest achievements so far I would say."
Tickets will be available to purchase on the gate on Sunday.
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